A healthcare professional may prescribe it to treat severe pain. A person taking prescribed fentanyl can experience dependence, meaning they have withdrawal symptoms when they stop taking the drug. In this article, we will discuss the medical uses of fentanyl and its side effects. We will also cover misuse of fentanyl, addiction, and the risk of overdose. CDC is committed to addressing the opioid overdose epidemic and supporting states and communities as they continue work to identify outbreaks, collect data, respond to overdoses, and provide care to those in their communities. Because the drug is less expensive than other opioids, people making it illegally commonly mix it into drugs such as heroin, cocaine, or methamphetamines.
- For example, a death that involved both heroin and fentanyl would be included in both the number of drug overdose deaths involving heroin and the number of drug overdose deaths involving synthetic opioids other than methadone.
- The distinct indicators of a fentanyl and alcohol overdose may encompass seizure, slowed breathing, chest pain, loss of consciousness, and fatality.
- If you or someone you’re close to uses opioids or street drugs, these ideas may help protect them.
More survivors means more need for health care and addiction treatment
“The announcement of delays alone could trigger layoffs and program shutdowns. It could really start a chain reaction that’s hard to come back from,” the CDC staffer said. Stay with the patient while they await the arrival of emergency services. That matters because studies show people who survive addiction long enough do typically recover. “This trend in the reduction of substance use among teenagers is unprecedented,” Nora D. Volkow, who has served as director of the U.S. government’s National Institute on Drug Abuse since 2003, said in a statement last December.
Download the CDC Fact Sheet
However, illicit use is usually aimed at using a dose that will maximize euphoria, therefore increasing the dangers. There have been no clinically confirmed overdoses (breathing slowed or stopped) from people who breathed in secondhand fentanyl smoke. “Secondhand fentanyl smoke” is smoke coming off a burning pill or powder, or breathed out by someone who smoked fentanyl. Pharmaceutical fentanyl is safer when used exactly as prescribed, but it still carries a high risk of addiction and overdose. Doctors are prescribing it less frequently these days due to heightened awareness of the fentanyl-driven opioid crisis and the risks of misuse. Staten Island is leading New York City with the steepest percent decline in fatal drug overdoses among the five boroughs.
National Resources

Provisional counts are often incomplete and causes of death may be pending investigation (see Technical notes) resulting in an underestimate relative to final counts. To address this, methods were developed to adjust provisional counts for reporting delays by generating a set of predicted provisional counts (see Technical notes). Fentanyl is a synthetic opioid with a potency 50 times greater than heroin and 100 times that of morphine. Even small amounts can lead to overdose due to its extreme potency, which carries a significant risk of respiratory depression – the primary cause of death in fentanyl how long does fentanyl stay in your system overdoses. Its lethal strength means that even a minuscule dose can result in severe, potentially fatal, consequences. Individuals susceptible to fentanyl overdoses may include younger patients, first-time opioid users, and those with no tolerance to opioids.
What types of treatment are available for people with substance use disorder?
- Please contact your local public health authority to learn more about services nearest to you.
- Call an ambulance right away if you suspect you or someone you’re with may have taken an overdose.
- The drowsiness and unconsciousness that often follow fentanyl ingestion are primarily attributed to its impact on the central nervous system, specifically through sedation and respiratory depression.
Values for records pending investigation are updated with each monthly release and reflect the most current data available. Methods were developed to adjust provisional counts for reporting delays related to temporal factors (i.e., 12 month-ending period) and the percentage of records that are reported with manner of death “pending investigation” (2). Briefly, these methods involve developing ‘multiplication factors’ based on the degree of underreporting in provisional data compared with final data. For example, if provisional counts of drug overdose deaths were historically 90% complete relative to final data, then the multiplication factor in this instance would be 1.1.

NPR Exclusive: U.S. overdose deaths plummet, saving thousands of lives
Individuals who consume IMF should take harm reduction measures such as using clean smoking equipment or syringes, avoid using alone and ensure that naloxone is readily available in the case of an overdose. EDs reporting consistent and complete data during the study period.¶ Counts of fentanyl-involved nonfatal overdoses and total ED visits for any cause were aggregated quarterly, overall and by age group, sex, and race and ethnicity. Persons aged 0–14 years were excluded from the age-specific analysis https://mesnicagold.com/sober-living/understanding-alcohols-impact-on-your-body-as-you/ because of data suppression criteria (fewer than 20 cases per quarter). Persons of Hispanic or Latino (Hispanic) ethnicity, irrespective of race, were classified as Hispanic. For the remaining categories, non-Hispanic persons were reported by their indicated single race classification (i.e., American Indian or Alaska Native AI/AN, Black or African American Black, White, or other race). Asian, multiple race, other race, and Native Hawaiian or Pacific Islander persons were aggregated into the other race category because of small counts.
What are the signs of fentanyl overdose?
The citrate salt, fentanyl citrate, is administered by injection, either intramuscularly or intravenously, sometimes in combination with a potent tranquilizer. Nebraska had the lowest death rate in 2023, Twelve-step program with 3.3 fentanyl overdoses per 100,000 residents. In 2023, fentanyl was responsible for about 199 deaths every day. Over a quarter of a million Americans have died from fentanyl overdoses since 2021.
The Three Waves of America’s Opioid Crisis
Naloxone safely reverses the effects of an opioid overdose and has saved countless lives. It is available over-the-counter at pharmacies across all 50 states. The federal government’s public health response reflects a significant and pragmatic shift toward embracing harm reduction—a strategy focused on keeping people alive and as safe as possible, even if they continue to use drugs. Overdose deaths involving prescription opioids began a steady climb that started in 1999, marking the beginning of the first wave. The roots of the modern opioid epidemic trace back to the late 1990s, when there was a dramatic increase in the volume of opioid medications prescribed by doctors in the United States.
Between 2022 and 2023, rates of drug overdose deaths decreased for people ages 15–54 and increased for adults age 55 and older. The age-adjusted rate of drug overdose deaths declined 4.0% between 2022 and 2023, which follows a nonsignificant increase between 2021 and 2022 (1). Previously, rates had generally increased across most years over the period 2003–2023. As an elevated train rumbled overhead, Carlyle described turning to fentanyl, xylazine and other increasingly toxic street drugs. “I’ve had three overdoses, and two of the times I was definitely Narcaned,” he said, referring to a medication, also known as naloxone, that reverses potentially fatal opioid overdoses.
We must address the factors contributing to the fentanyl crisis on multiple fronts. While the paths to recovery can differ, understanding patterns of treatment, support services, and the duration of substance use offers valuable insights for helping others on their recovery journey. These sanctions make it illegal for any U.S. person, bank, or company to do business with the designated entities. Homeland Security Investigations serves as the primary investigative body within DHS. HSI agents conduct long-term, cross-border investigations targeting the full range of activities of transnational criminal organizations, including not only drug smuggling but also money laundering and arms trafficking.
